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Ionic Cell Signalling - publications archive
Publications
- Flecainide reduces Ca2+ spark and wave frequency via inhibition of the sarcolemmal sodium current.
Sikkel MB, Collins TP, Rowlands C, Shah M, O'Gara P, Williams AJ, Harding SE, Lyon AR, Macleod KT,
Cardiovasc Res,
Volume 98,
2
(May 2013)
pp.286-296
- The effect of inorganic arsenic on endothelium-dependent relaxation: Role of NADPH oxidase and hydrogen peroxide.
Edwards DH, Li Y, Ellinsworth DC, Griffith TM,
Toxicology,
Volume 306
(April 2013)
pp.50-58
- PLCζ and the initiation of Ca(2+) oscillations in fertilizing mammalian eggs.
Swann K, Lai FA,
Cell Calcium,
Volume 53,
1
(January 2013)
pp.55-62
- The dynamics of PKC-induced phosphorylation triggered by Ca2+ oscillations in mouse eggs.
Gonzalez-Garcia JR, Machaty Z, Lai FA, Swann K,
J Cell Physiol,
Volume 228,
1
(January 2013)
pp.110-119
- Phospholipase Cζ rescues failed oocyte activation in a prototype of male factor infertility.
Nomikos M, Yu Y, Elgmati K, Theodoridou M, Campbell K, Vassilakopoulou V, Zikos C, Livaniou E, Amso N, Nounesis G, Swann K, Lai FA,
Fertil Steril,
Volume 99,
1
(January 2013)
pp.76-85
- Ca2+ activation of cytosolic calpain induces the transition from apoptosis to necrosis in neutrophils with externalized phosphatidylserine.
Francis RJ, Kotecha S, Hallett MB,
J Leukoc Biol,
Volume 93,
1
(January 2013)
pp.95-100
- Measuring Ca2+ oscillations in mammalian eggs.
Swann K,
Methods Mol Biol,
Volume 957
(2013)
pp.231-248
- A network-oriented perspective on cardiac calcium signaling.
George CH, Parthimos D, Silvester NC,
Am J Physiol Cell Physiol,
Volume 303,
9
(November 2012)
pp.C897-C910
- Potent inhibition of Ca2+-dependent activation of calpain-1 by novel mercaptoacrylates
Adams SE, Parr C, Miller DJ, Allemann RK, Hallett MB,
Medchemcomm,
Volume 3,
5
(May 2012)
pp.566-570
- Disparities in the association of the ryanodine receptor and the FK506-binding proteins in mammalian heart.
Zissimopoulos S, Seifan S, Maxwell C, Williams AJ, Lai FA,
J Cell Sci,
Volume 125,
Pt 7
(April 2012)
pp.1759-1769
- Obituary: Professor Tudor Griffith, MA, MB BCh, PhD, MRCP, FRCR
Edwards DH,
European Heart Journal,
Volume 33,
5
(March 2012)
pp.547-547
- Phospholipase C-ζ-induced Ca2+ oscillations cause coincident cytoplasmic movements in human oocytes that failed to fertilize after intracytoplasmic sperm injection.
Swann K, Windsor S, Campbell K, Elgmati K, Nomikos M, Zernicka-Goetz M, Amso N, Lai FA, Thomas A, Graham C,
Fertil Steril,
Volume 97,
3
(March 2012)
pp.742-747
- Starting a new life: sperm PLC-zeta mobilizes the Ca2+ signal that induces egg activation and embryo development: an essential phospholipase C with implications for male infertility.
Nomikos M, Swann K, Lai FA,
Bioessays,
Volume 34,
2
(February 2012)
pp.126-134
- PLCζ causes Ca(2+) oscillations in mouse eggs by targeting intracellular and not plasma membrane PI(4,5)P(2).
Yu Y, Nomikos M, Theodoridou M, Nounesis G, Lai FA, Swann K,
Mol Biol Cell,
Volume 23,
2
(January 2012)
pp.371-380
- Techniques and methodologies to study the ryanodine receptor at the molecular, subcellular and cellular level.
Viero C, Thomas NL, Euden J, Mason SA, George CH, Williams AJ,
Adv Exp Med Biol,
Volume 740
(2012)
pp.183-215
- Pharmacology of ryanodine receptors and CICR
Thomas LN, Williams AJ,
Wires Membrane Transport And Signalling,
Volume 1
(2012)
pp.383-397
- Searching for new cardiovascular drugs: towards improved systems for drug screening?
Silvester NC, George CH,
Expert Opinion On Drug Discovery,
Volume 6,
11
(November 2011)
pp.1155-1170
- Novel regulation of PLCζ activity via its XY-linker.
Nomikos M, Elgmati K, Theodoridou M, Georgilis A, Gonzalez-Garcia JR, Nounesis G, Swann K, Lai FA,
Biochem J,
Volume 438,
3
(September 2011)
pp.427-432
- Divergent effect of mammalian PLCζ in generating Ca²⁺ oscillations in somatic cells compared with eggs.
Phillips SV, Yu Y, Rossbach A, Nomikos M, Vassilakopoulou V, Livaniou E, Cumbes B, Lai FA, George CH, Swann K,
Biochem J,
Volume 438,
3
(September 2011)
pp.545-553
- Phospholipase Cζ binding to PtdIns(4,5)P2 requires the XY-linker region.
Nomikos M, Elgmati K, Theodoridou M, Calver BL, Nounesis G, Swann K, Lai FA,
J Cell Sci,
Volume 124,
Pt 15
(August 2011)
pp.2582-2590
- Rhythmic actomyosin-driven contractions induced by sperm entry predict mammalian embryo viability
Ajduk A, Ilozue T, Windsor S, Yu Y, Seres KB, Bomphrey RJ, Tom BD, Swann K, Thomas A, Graham C, Zernicka-Goetz M,
Nature Communications,
Volume 2
(August 2011)
- Spatial organization of RYRs and BK channels underlying the activation of STOCs by Ca(2+) sparks in airway myocytes.
Lifshitz LM, Carmichael JD, Lai FA, Sorrentino V, Bellvé K, Fogarty KE, ZhuGe R,
J Gen Physiol,
Volume 138,
2
(August 2011)
pp.195-209
- Extracellular ATP induces spikes in cytosolic free Ca(2+) but not in NADPH oxidase activity in neutrophils.
Brasen JC, Olsen LF, Hallett MB,
Biochim Biophys Acta,
Volume 1813,
8
(August 2011)
pp.1446-1452
- In vivo functional analysis and genetic modification of in vitro-derived mouse neutrophils.
McDonald JU, Cortini A, Rosas M, Fossati-Jimack L, Ling GS, Lewis KJ, Dewitt S, Liddiard K, Brown GD, Jones SA, Hallett MB, Botto M, Taylor PR,
Faseb J,
Volume 25,
6
(June 2011)
pp.1972-1982
- Male infertility-linked point mutation disrupts the Ca2+ oscillation-inducing and PIP2 hydrolysis activity of sperm PLC zeta (vol 434, pg 211, 2011)
Nomikos M, Elgmati K, Theodoridou M, Calver BL, Cumbes B, Nounesis G, Swann K, Lai FA,
Biochemical Journal,
Volume 435
(May 2011)
pp.791-791
- Male infertility-linked point mutation disrupts the Ca2+ oscillation-inducing and PIP2 hydrolysis activity of sperm PLCζ.
Nomikos M, Elgmati K, Theodoridou M, Calver BL, Cumbes B, Nounesis G, Swann K, Lai FA,
Biochem J,
Volume 435,
3
(May 2011)
pp.791-791
- Ezrin and talin relocates from the plasma membrane to cytosol during neutrophil extravasation
Elumalai GL, Dewitt S, Hallett MB,
European Journal Of Clinical Investigation,
Volume 41
(April 2011)
pp.47-47
- Calpain-1: investigating its role in murine neutrophils
Ishak R, Dewitt S, Hallett MB,
European Journal Of Clinical Investigation,
Volume 41
(April 2011)
pp.24-24
- The role of calpain translocation in neutrophil spreading
Lewis KJ, Dewitt S, Hallett MB,
European Journal Of Clinical Investigation,
Volume 41
(April 2011)
pp.47-47
- Ca2+ events in apoptosis and necrosis of neutrophils
Francis RJ, Kotecha S, Hallett MB,
European Journal Of Clinical Investigation,
Volume 41
(April 2011)
pp.46-47
- Male infertility-linked point mutation disrupts the Ca2+ oscillation-inducing and PIP(2) hydrolysis activity of sperm PLCζ.
Nomikos M, Elgmati K, Theodoridou M, Calver BL, Cumbes B, Nounesis G, Swann K, Lai FA,
Biochem J,
Volume 434,
2
(March 2011)
pp.211-217
- A trick of the light: the optical properties of living cytoplasm which can mislead.
Hallett MB, Dewitt S,
Integr Biol (Camb),
Volume 3,
3
(March 2011)
pp.180-184
- CMV promoter is inadequate for expression of mutant human RyR2 in transgenic rabbits.
Wakula P, Bisping E, Kockskämper J, Post H, Brauer S, Deuter M, Oehlmann R, Besenfelder U, Lai FA, Brem G, Pieske B,
J Pharmacol Toxicol Methods,
Volume 63,
2
(March 2011)
pp.180-185
- Optical complexities of living cytoplasm--implications for live cell imaging and photo-micromanipulation techniques.
Dewitt S, Hallett MB,
J Microsc,
Volume 241,
3
(March 2011)
pp.221-224
- Targeted Inhibition of Connexin 43 Hemichannels Blunts Ca2+-Induced Intercellular Dyssynchrony and ATP Efflux in Hl-1 Cardiomyocyte Syncitia
Silvester NC, Jundi H, Jayanthi A, Barberini-Jammaers SR, Evans WH, George CH,
Biophysical Journal,
Volume 100
(2011)
pp.564-564
- Trans Complementation with the Common G1885E Polymorphism Attenuates Mutant RyR2 L433P Channel Dysfunction
Clack AI, Thomas NL, Silvester NC, Barberini-Jammaers SR, Lai FA, George CH,
Biophysical Journal,
Volume 100
(2011)
pp.415-415
- Redistribution of mitochondria leads to bursts of ATP production during spontaneous mouse oocyte maturation.
Yu Y, Dumollard R, Rossbach A, Lai FA, Swann K,
J Cell Physiol,
Volume 224,
3
(September 2010)
pp.672-680
- How does CaMKII delta phosphorylation of the cardiac ryanodine receptor contribute to inotropy?
Eisner DA, George CH, Smith GL, Trafford AW, Venetucci LA,
Proceedings Of The National Academy Of Sciences Of The United States Of America,
Volume 107,
31
(August 2010)
pp.E123-E123
- Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation.
Sedej S, Heinzel FR, Walther S, Dybkova N, Wakula P, Groborz J, Gronau P, Maier LS, Vos MA, Lai FA, Napolitano C, Priori SG, Kockskämper J, Pieske B,
Cardiovasc Res,
Volume 87,
1
(July 2010)
pp.50-59
- Ryanodine receptor mutations in arrhythmia: The continuing mystery of channel dysfunction.
Thomas NL, Maxwell C, Mukherjee S, Williams AJ,
Febs Lett,
Volume 584,
10
(May 2010)
pp.2153-2160
- Bioinformatic mapping and production of recombinant N-terminal domains of human cardiac ryanodine receptor 2.
Bauerová-Hlinková V, Hostinová E, Gasperík J, Beck K, Borko L, Lai FA, Zahradníková A, Sevcík J,
Protein Expr Purif,
Volume 71,
1
(May 2010)
pp.33-41
- A reporter of UV intensity delivered to the cytosol during photolytic uncaging.
Brasen JC, Dewitt S, Hallett MB,
Biophys J,
Volume 98,
7
(April 2010)
pp.L25-L27
- Cell surface topology creates high Ca2+ signalling microdomains.
Brasen JC, Olsen LF, Hallett MB,
Cell Calcium,
Volume 47,
4
(April 2010)
pp.339-349
- A mechanism of ryanodine receptor modulation by FKBP12/12.6, protein kinase A, and K201.
Blayney LM, Jones JL, Griffiths J, Lai FA,
Cardiovasc Res,
Volume 85,
1
(January 2010)
pp.68-78
- Biophysical and Cellular Characterisation of Alternatively Spliced Isoforms of the Human Cardiac Ryanodine Receptor (RyR2)
Yeung WY, Thomas NL, Mukherjee S, Davies MV, Lai FA, Williams AJ, George CH,
Biophysical Journal,
Volume 98
(2010)
pp.298-298
- Adaptive Retuning of Small Ca2+ Fluxes in Cardiomyocyte Syncytia Predicts the Response To Pro-Arrhythmic Stimuli
Silvester NC, Ashton PM, Barberini-Jammaers SR, Lai FA, George CH,
Biophysical Journal,
Volume 98
(2010)
pp.105-105
- Attenuated store-operated Ca2+ entry underpins the dual inhibition of nitric oxide and EDHF-type relaxations by iodinated contrast media.
Fernandez-Rodriguez S, Edwards DH, Newton B, Griffith TM,
Cardiovasc Res,
Volume 84,
3
(December 2009)
pp.470-478
- Ascorbic acid and tetrahydrobiopterin potentiate the EDHF phenomenon by generating hydrogen peroxide.
Garry A, Edwards DH, Fallis IF, Jenkins RL, Griffith TM,
Cardiovasc Res,
Volume 84,
2
(November 2009)
pp.218-226
- Myocardial stunning is associated with impaired calcium uptake by sarcoplasmic reticulum.
Kumar S, Hall RJ, Mani AR, Moore KP, Camici PG, Rimoldi OE, Williams AJ, Macleod KT,
Biochem Biophys Res Commun,
Volume 387,
1
(September 2009)
pp.77-82
- Ryanodine receptor-mediated arrhythmias and sudden cardiac death.
Blayney LM, Lai FA,
Pharmacol Ther,
Volume 123,
2
(August 2009)
pp.151-177
- Soluble TLR2 reduces inflammation without compromising bacterial clearance by disrupting TLR2 triggering.
Raby AC, Le Bouder E, Colmont C, Davies J, Richards P, Coles B, George CH, Jones SA, Brennan P, Topley N, Labéta MO,
J Immunol,
Volume 183,
1
(July 2009)
pp.506-517
- Fantastic Ca2+ "z-waves" fade out quietly.
Hallett MB, Lebiedz D, Mommer MS, Reble C, Saltmarsh EJ,
Cell Calcium,
Volume 46,
1
(July 2009)
pp.85-86
- Mitochondrial function and redox state in mammalian embryos
Dumollard R, Carroll J, Duchen MR, Campbell K, Swann K,
Seminars In Cell & Developmental Biology,
Volume 20,
3
(May 2009)
pp.346-353
- Mineralocorticoid modulation of cardiac ryanodine receptor activity is associated with downregulation of FK506-binding proteins.
Gómez AM, Rueda A, Sainte-Marie Y, Pereira L, Zissimopoulos S, Zhu X, Schaub R, Perrier E, Perrier R, Latouche C, Richard S, Picot MC, Jaisser F, Lai FA, Valdivia HH, Benitah JP,
Circulation,
Volume 119,
16
(April 2009)
pp.2179-2187
- FKBP12.6 binding of ryanodine receptors carrying mutations associated with arrhythmogenic cardiac disease.
Zissimopoulos S, Thomas NL, Jamaluddin WW, Lai FA,
Biochem J,
Volume 419,
2
(April 2009)
pp.273-278
- Perturbing plasma membrane hemichannels attenuates calcium signalling in cardiac cells and HeLa cells expressing connexins
Verma V, Hallett MB, Leybaert L, Martin PE, Evans WH,
European Journal Of Cell Biology,
Volume 88,
2
(February 2009)
pp.79-90
- Perturbing plasma membrane hemichannels attenuates calcium signalling in cardiac cells and HeLa cells expressing connexins.
Verma V, Hallett MB, Leybaert L, Martin PE, Evans WH,
Eur J Cell Biol,
Volume 88,
2
(February 2009)
pp.79-90
- Use of luciferase chimaera to monitor PLCzeta expression in mouse eggs.
Swann K, Campbell K, Yu Y, Saunders C, Lai FA,
Methods Mol Biol,
Volume 518
(2009)
pp.17-29
- Investigating the Ca2+-Cycling Basis of Rhythmicity and Synchronicity inCoupled Cardiomyocyte Monolayers
Silvester NC, Barberini-Jammaers SR, Ashton PM, Jayanthi A, Yeung WY, Jundi H, Kotecha A, Lai FA, George CH,
Biophysical Journal,
Volume 96
(2009)
pp.273-273
- Decoding The Molecular Basis Of Anti-Apoptotic Cardiac Ca2+ Signalling Via Human RyR2 Splice Variants
Yeung WY, Davies M, Lai FA, Williams AJ, George CH,
Biophysical Journal,
Volume 96
(2009)
pp.111-111
- Targeted Stabilisation Of The RyR2 I-Domain Restores Ca2+ Handling And Intercellular Synchrony In Ouabain-disrupted Cardiac Cell Monolayers
Jundi H, Lai FA, George CH,
Biophysical Journal,
Volume 96
(2009)
pp.113-113
- Vasomotion: the case for chaos
Griffith, TM None, Parthimos, D None, Edwards DH,
Journal Of Biorheology,
Volume 23,
1
(2009)
pp.11-23
- An L433P Arrhythmia-linked Mutation In RyR2 Uncouples Agonist-evoked Ca2+ Release From Homeostatic Ca2+ Cycling
Clack AI, Fry DL, Thomas NL, Lai FA, George CH,
Biophysical Journal,
Volume 96
(2009)
pp.111-111
- Fertilization differently affects the levels of cyclin B1 and M-phase promoting factor activity in maturing and metaphase II mouse oocytes
Ajduk A, Ciemerych MA, Nixon V, Swann K, Maleszewski M,
Reproduction,
Volume 136,
6
(December 2008)
pp.741-752
- Immature circulating neutrophils in sepsis have impaired phagocytosis and calcium signaling.
Taneja R, Sharma AP, Hallett MB, Findlay GP, Morris MR,
Shock,
Volume 30,
6
(December 2008)
pp.618-622
- Regulation of diacylglycerol production and protein kinase C stimulation during sperm- and PLCzeta-mediated mouse egg activation.
Yu Y, Halet G, Lai FA, Swann K,
Biol Cell,
Volume 100,
11
(November 2008)
pp.633-643
- Stopping the traffic: a route to arthritis therapy.
Hallett MB, Williams AS,
Eur J Immunol,
Volume 38,
10
(October 2008)
pp.2650-2653
- Chemotaxis and the cell surface-area problem.
Hallett MB, von Ruhland CJ, Dewitt S,
Nat Rev Mol Cell Biol,
Volume 9,
8
(August 2008)
p. 662
- Genetic polymorphisms in beta 1 and beta 2 adrenergic receptors: Variations without a theme?
George CH,
Heart Rhythm,
Volume 5,
6
(June 2008)
pp.822-825
- Regulation of cytosolic and mitochondrial ATP levels in mouse eggs and zygotes
Dumollard R, Campbell K, Halet G, Carroll J, Swann K,
Developmental Biology,
Volume 316,
2
(April 2008)
pp.431-440
- Evidence for serca and BKCa activation in BNP protection of reperfused myocardium
Burley DS, George CH, Wann KT, Baxter GF,
Journal Of Molecular And Cellular Cardiology,
Volume 44,
4
(April 2008)
pp.717-717
- Addressing controversy in localised Ca2+ signals in human neutrophils
Saltmarsh-Hillson EJ, Hallett MB,
European Journal Of Clinical Investigation,
Volume 38
(April 2008)
pp.62-62
- Ryanodine receptor arrays: not just a pretty pattern?
Yin CC, D'Cruz LG, Lai FA,
Trends Cell Biol,
Volume 18,
4
(April 2008)
pp.149-156
- Modification of smooth muscle Ca2+-sparks by tetracaine: evidence for sequential RyR activation.
Curtis TM, Tumelty J, Stewart MT, Arora AR, Lai FA, McGahon MK, Scholfield CN, McGeown JG,
Cell Calcium,
Volume 43,
2
(February 2008)
pp.142-154
- Preimplantation development of mouse oocytes activated by different levels of human phospholipase C zeta.
Yu Y, Saunders CM, Lai FA, Swann K,
Hum Reprod,
Volume 23,
2
(February 2008)
pp.365-373
- Sarcoplasmic reticulum Ca2+ leak in heart failure: mere observation or functional relevance?
George CH,
Cardiovascular Research,
Volume 77,
2
(January 2008)
pp.302-314
- Refocussing therapeutic strategies for cardiac arrhythmias: defining viable molecular targets to restore cardiac ion flux
George CH, Barberini-Jammaers SR, Muller CT,
Expert Opinion On Therapeutic Patents,
Volume 18,
1
(January 2008)
pp.1-19
- The dynamics of calcium oscillations that activate mammalian eggs.
Swann K, Yu Y,
Int J Dev Biol,
Volume 52,
5-6
(2008)
pp.585-594
- Physiological consequences of the P2328S mutation in the ryanodine receptor (RyR2) gene in genetically modified murine hearts
Goddard C, Ghais N, Zhang Y, Williams A, Colledge W, Grace A, Huang C,
Acta Physiol,
Volume 194
(2008)
pp.123-140
- Ca2+ influx shutdown in neutrophils induced by Fas (CD95) cross-linking (vol 112, pg 454, 2004)
Ayub K, Laffafian I, Dewitt S, Hallett MB,
Immunology,
Volume 122,
4
(December 2007)
pp.634-634
- Ryanodine receptor mutations in arrhythmias: advances in understanding the mechanisms of channel dysfunction.
Thomas NL, George CH, Williams AJ, Lai FA,
Biochem Soc Trans,
Volume 35,
Pt 5
(November 2007)
pp.946-951
- Ryanodine receptor mutations in arrhythmias: advances in understanding the mechanisms of channel dysfunction
Thomas NL, George CH, Williams AJ, Lai FA,
Biochemical Society Transactions,
Volume 35
(November 2007)
pp.946-951
- Composition of sea urchin egg homogenate determines its potency to inositol trisphosphate and cyclic ADPRibose-induced Ca2+ release
Jones KT, Swann K,
Biochemical And Biophysical Research Communications,
Volume 360,
4
(September 2007)
pp.815-820
- Phospholipid binding properties and functional characterization of a sea urchin phospholipase C delta in urchin and mouse eggs
Coward K, Owen H, Tunwell R, Swann K, Parrington J,
Biochemical And Biophysical Research Communications,
Volume 357,
4
(June 2007)
pp.964-970
- Binding of phosphoinositide-specific phospholipase C-zeta (PLC-zeta) to phospholipid membranes: potential role of an unstructured cluster of basic residues.
Nomikos M, Mulgrew-Nesbitt A, Pallavi P, Mihalyne G, Zaitseva I, Swann K, Lai FA, Murray D, McLaughlin S,
J Biol Chem,
Volume 282,
22
(June 2007)
pp.16644-16653
- Localised and rapid Ca2+ micro-events in human neutrophils: conventional Ca2+ puffs and global waves without peripheral-restriction or wave cycling.
Hillson EJ, Hallett MB,
Cell Calcium,
Volume 41,
6
(June 2007)
pp.525-536
- Alternative splicing of ryanodine receptors modulates cardiomyocyte Ca2+ signaling and susceptibility to apoptosis.
George CH, Rogers SA, Bertrand BM, Tunwell RE, Thomas NL, Steele DS, Cox EV, Pepper C, Hazeel CJ, Claycomb WC, Lai FA,
Circ Res,
Volume 100,
6
(March 2007)
pp.874-883
- Redox sensitivity of the ryanodine receptor interaction with FK506-binding protein.
Zissimopoulos S, Docrat N, Lai FA,
J Biol Chem,
Volume 282,
10
(March 2007)
pp.6976-6983
- Molecular nature of sulfhydryl modification by hydrogen peroxide on type 1 ryanodine receptor. (vol 27, pg 888, 2006)
Han H, Wei R, Lai FA, Yin C,
Acta Pharmacologica Sinica,
Volume 28,
3
(March 2007)
pp.430-430
- Lipid-protein cargo transfer: a mode of direct cell-to-cell communication for lipids and their associated proteins.
Laffafian I, Hallett MB,
J Cell Physiol,
Volume 210,
2
(February 2007)
pp.336-342
- Targeting the RyR2 I-domain as a novel strategy to correct mutationlinked Ca2+ release channel dysfunction.
Jundi H, Lai FA, George CH,
Biophysical Journal
(January 2007)
pp.262A-262A
- Modulating intracellular Ca2+ signaling using recombinant fragments of the human cardiac ryanodine receptor (RyR2)
Fry DL, Jundi H, Thomas NL, Lai FA, George CH,
Biophysical Journal
(January 2007)
pp.260A-260A
- Ryanodine receptors and ventricular arrhythmias: Emerging trends in mutations, mechanisms and therapies
George CH, Jundi H, Thomas NL, Fry DL, Lai FA,
Journal Of Molecular And Cellular Cardiology,
Volume 42,
1
(January 2007)
pp.34-50
- Ryanodine receptors and ventricular arrhythmias: emerging trends in mutations, mechanisms and therapies.
George CH, Jundi H, Thomas NL, Fry DL, Lai FA,
J Mol Cell Cardiol,
Volume 42,
1
(January 2007)
pp.34-50
- Developing new anti-arrhythmics: clues from the molecular basis of cardiac ryanodine receptor (RyR2) Ca2+-release channel dysfunction.
George CH, Lai FA,
Curr Pharm Des,
Volume 13,
31
(2007)
pp.3195-3211
- Quantification of the effects of a ryanodine receptor channel mutation on interaction with a ryanoid
Ranatunga KM, Chen SRW, Ruest L, Welch W, Williams AJ,
Molecular Membrane Biology,
Volume 24,
3
(2007)
pp.185-1U4
- Pharmacological regulators of intracellular calcium release channels.
West DJ, Williams AJ,
Curr Pharm Des,
Volume 13,
24
(2007)
pp.2428-2442
- Optical methods for the measurement and manipulation of cytosolic free calcium in neutrophils.
Hillson EJ, Dewitt S, Hallett MB,
Methods Mol Biol,
Volume 412
(2007)
pp.125-137
- Modulation of gap-junction-dependent arterial relaxation by ascorbic acid.
Edwards DH, Chaytor AT, Bakker LM, Griffith TM,
J Vasc Res,
Volume 44,
5
(2007)
pp.410-422
- Phagocytosis of optically-trapped particles: delivery of the pure phagocytic signal.
Hallett MB,
Cell Res,
Volume 16,
11
(November 2006)
pp.852-854
- Role of ryanodine receptor mutations in cardiac pathology: more questions than answers?
Thomas NL, George CH, Lai FA,
Biochem Soc Trans,
Volume 34,
Pt 5
(November 2006)
pp.913-918
- Redox regulation of the ryanodine receptor/calcium release channel.
Zissimopoulos S, Lai FA,
Biochem Soc Trans,
Volume 34,
Pt 5
(November 2006)
pp.919-921
- Ca2+ oscillations stimulate an ATP increase during fertilization of mouse eggs.
Campbell K, Swann K,
Dev Biol,
Volume 298,
1
(October 2006)
pp.225-233
- Arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia: insights from a RyR2 R4496C knock-in mouse model.
Liu N, Colombi B, Memmi M, Zissimopoulos S, Rizzi N, Negri S, Imbriani M, Napolitano C, Lai FA, Priori SG,
Circ Res,
Volume 99,
3
(August 2006)
pp.292-298
- Dihydropyridine receptors and type 1 ryanodine receptors constitute the molecular machinery for voltage-induced Ca2+ release in nerve terminals.
De Crescenzo V, Fogarty KE, Zhuge R, Tuft RA, Lifshitz LM, Carmichael J, Bellvé KD, Baker SP, Zissimopoulos S, Lai FA, Lemos JR, Walsh JV,
J Neurosci,
Volume 26,
29
(July 2006)
pp.7565-7574
- The absence of a Ca(2+) signal during mouse egg activation can affect parthenogenetic preimplantation development, gene expression patterns, and blastocyst quality
Rogers NT, Halet G, Piao Y, Carroll J, Ko MSH, Swann K,
Reproduction,
Volume 132,
1
(July 2006)
pp.45-57
- Molecular nature of sulfhydryl modification by hydrogen peroxide on type 1 ryanodine receptor.
Han HM, Wei RS, Lai FA, Yin CC,
Acta Pharmacol Sin,
Volume 27,
7
(July 2006)
pp.888-894
- Ryanodine receptor interaction with the SNARE-associated protein snapin.
Zissimopoulos S, West DJ, Williams AJ, Lai FA,
J Cell Sci,
Volume 119,
Pt 11
(June 2006)
pp.2386-2397
- Ryanodine receptor mutations and ventricular arrhythmias: channel instability at the heart of Ca2+ release dysfunction
George CH,
Journal Of Molecular And Cellular Cardiology,
Volume 40,
6
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- The interaction of an impermeant cation with the sheep cardiac RyR channel alters ryanoid association.
Tanna B, Welch W, Ruest L, Sutko JL, Williams AJ,
Mol Pharmacol,
Volume 69,
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- PLCzeta(zeta): a sperm protein that triggers Ca2+ oscillations and egg activation in mammals.
Swann K, Saunders CM, Rogers NT, Lai FA,
Semin Cell Dev Biol,
Volume 17,
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pp.264-273
- Syntillas release Ca2+ at a site different from the microdomain where exocytosis occurs in mouse chromaffin cells.
ZhuGe R, DeCrescenzo V, Sorrentino V, Lai FA, Tuft RA, Lifshitz LM, Lemos JR, Smith C, Fogarty KE, Walsh JV,
Biophys J,
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- Arrhythmogenic mutation-linked defects in ryanodine receptor autoregulation reveal a novel mechanism of Ca2+ release channel dysfunction.
George CH, Jundi H, Walters N, Thomas NL, West RR, Lai FA,
Circ Res,
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- IP(3)-Induced Cell Spreading of Human Neutrophils Requires Ca(2+) Influx
Hillson EJ, Dewitt S, Hallett MB,
Molecular Biology Of The Cell,
Volume 17
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Dewitt S, Gil-Parrado S, Swann K, Hallett MB,
Molecular Biology Of The Cell,
Volume 17
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Ajduk A, Ciemerych MA, Swann K, Maleszewski M,
Acta Biologica Cracoviensia Series Botanica,
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- Potential Membrane Lipid Interaction Role for Charged Residues in the X-Y Linker Region of PLC zeta
Gonzalez-Garcia JR, Nomikos M, Pallavi P, Mihalyne G, Zaitseva I, Mulgrew-Nesbitt A, Murray D, McLaughlin S, Swann K, Lai FA,
Molecular Biology Of The Cell,
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Biochemical And Biophysical Research Communications,
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Jones JL, Reynolds DF, Lai FA, Blayney LM,
J Cell Sci,
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Morris MR, Doull IJ, Dewitt S, Hallett MB,
Clin Exp Immunol,
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- Role of phospholipase C-zeta domains in Ca2+-dependent phosphatidylinositol 4,5-bisphosphate hydrolysis and cytoplasmic Ca2+ oscillations.
Nomikos M, Blayney LM, Larman MG, Campbell K, Rossbach A, Saunders CM, Swann K, Lai FA,
J Biol Chem,
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- The Gln4863Ala mutation within a putative, pore-lining trans-membrane helix of the cardiac ryanodine receptor channel alters both the kinetics of ryanoid interaction and the subsequent fractional conductance.
Ranatunga KM, Moreno-King TM, Tanna B, Wang R, Chen SR, Ruest L, Welch W, Williams AJ,
Mol Pharmacol,
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Griffith TM, Chaytor AT, Bakker LM, Edwards DH,
Proceedings Of The National Academy Of Sciences Of The United States Of America,
Volume 102,
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George CH, Thomas NL, Lai FA,
Future Cardiol,
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- Is fish oil good or bad for heart disease? Two trials with apparently conflicting results.
Burr ML, Dunstan FD, George CH,
J Membr Biol,
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J Mol Biol,
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- Differential Ca2+ sensitivity of RyR2 mutations reveals distinct mechanisms of channel dysfunction in sudden cardiac death
Thomas NL, Lai FA, George CH,
Biochemical And Biophysical Research Communications,
Volume 331,
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pp.231-238
- Differential Ca2+ sensitivity of RyR2 mutations reveals distinct mechanisms of channel dysfunction in sudden cardiac death.
Thomas NL, Lai FA, George CH,
Biochem Biophys Res Commun,
Volume 331,
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- Characterization of a novel PKA phosphorylation site, serine-2030, reveals no PKA hyperphosphorylation of the cardiac ryanodine receptor in canine heart failure.
Xiao B, Jiang MT, Zhao M, Yang D, Sutherland C, Lai FA, Walsh MP, Warltier DC, Cheng H, Chen SR,
Circ Res,
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Tanna B, Welch W, Ruest L, Sutko JL, Williams AJ,
Biophys J,
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Zissimopoulos S, Lai FA,
J Biol Chem,
Volume 280,
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- Two-dimensional crystallization of the ryanodine receptor Ca2+ release channel on lipid membranes.
Yin CC, Han H, Wei R, Lai FA,
J Struct Biol,
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- In situ characterisation of the Ca2+ sensitivity of cardiac RyR mutations reveals multiple mechanisms of channel dysfunction in sudden death
Thomas L, George C, Lai A,
Biophysical Journal,
Volume 88,
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pp.308A-309A
- Visualisation of intra-RyR2 interactions in HL-1 cardiomyocytes: novel FRET probes reveal a structural basis for Ca2+ channel dysfunction in arrhythmogenesis.
George CH, Walters N, Thomas NL, Yeung WY, Reynolds DF, Lai FA,
Biophysical Journal,
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- Connexin-mimetic peptides dissociate electrotonic EDHF-type signalling via myoendothelial and smooth muscle gap junctions in the rabbit iliac artery.
Chaytor AT, Bakker LM, Edwards DH, Griffith TM,
Br J Pharmacol,
Volume 144,
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- Phospholipase C causes Ca2+ oscillations and parthenogenetic activation of human oocytes (vol 128, pg 697, 2004)
Rogers NT, Hobson E, Pickering S, Lai FA, Braude P, Swann K,
Reproduction,
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- Toward a molecular understanding of the structure-function of ryanodine receptor Ca2+ release channels - Perspectives from recombinant expression systems
George CH, Yin CC, Lai FA,
Cell Biochemistry And Biophysics,
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- Central domain of the human cardiac muscle ryanodine receptor does not mediate interaction with FKBP12.6.
Zissimopoulos S, Lai FA,
Cell Biochem Biophys,
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George CH, Yin CC, Lai FA,
Cell Biochem Biophys,
Volume 42,
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pp.197-222
- Phospholipase C zeta causes Ca(2+) oscillations and parthenogenetic activation of human oocytes
Rogers NT, Hobson E, Pickering S, Lai FA, Braude P, Swann K,
Reproduction,
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pp.697-702
- Electrostatic mechanisms underlie neomycin block of the cardiac ryanodine receptor channel (RyR2).
Mead FC, Williams AJ,
Biophys J,
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- Phospholipase Czeta causes Ca2+ oscillations and parthenogenetic activation of human oocytes.
Rogers NT, Hobson E, Pickering S, Lai FA, Braude P, Swann K,
Reproduction,
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pp.697-702
- Functional heterogeneity of ryanodine receptor mutations associated with sudden cardiac death
Thomas LN, George CH, Lai FA,
Cardiovascular Research,
Volume 64,
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Thomas NL, George CH, Lai FA,
Cardiovasc Res,
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Scoote M, Williams AJ,
Biochem Biophys Res Commun,
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Welch W, Rheault S, West DJ, Williams AJ,
Biophysical Journal,
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- The mitochondrial ADPR link between Ca2+ store release and Ca2+ influx channel opening in immune cells.
Ayub K, Hallett MB,
Faseb J,
Volume 18,
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Ayub K, Hallett MB,
Aging Cell,
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- Ca2+ influx shutdown in neutrophils induced by Fas (CD95) cross-linking
Ayub K, Laffafian I, Dewitt S, Hallett MB,
Immunology,
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- Ca influx shutdown in neutrophils induced by Fas (CD95) cross-linking.
Ayub K, Laffafian I, Dewitt S, Hallett MB,
Immunology,
Volume 112,
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- Gap junctions - the obligatory link
Griffith TM, Chaytor AT, Edwards DH,
Fundamental & Clinical Pharmacology,
Volume 18
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pp.7-7
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George CH, Jundi H, Thomas NL, Scoote M, Walters N, Williams AJ, Lai FA,
Molecular Biology Of The Cell,
Volume 15,
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pp.2627-2638
- The obligatory link: role of gap junctional communication in endothelium-dependent smooth muscle hyperpolarization.
Griffith TM, Chaytor AT, Edwards DH,
Pharmacol Res,
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pp.551-564
- Ryanodine receptor regulation by intramolecular interaction between cytoplasmic and transmembrane domains.
George CH, Jundi H, Thomas NL, Scoote M, Walters N, Williams AJ, Lai FA,
Mol Biol Cell,
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Clayton A, Turkes A, Dewitt S, Steadman R, Mason MD, Hallett MB,
Faseb J,
Volume 18,
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- Cell cycle-dependent Ca2+ oscillations in mouse embryos are regulated by nuclear targeting of PLCzeta.
Larman MG, Saunders CM, Carroll J, Lai FA, Swann K,
J Cell Sci,
Volume 117,
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- Cell cycle-dependent Ca(2+) oscillations in mouse embryos are regulated by nuclear targeting of PLC zeta
Larman MG, Saunders CM, Carroll J, Lai FA, Swann K,
Journal Of Cell Science,
Volume 117,
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- Deterministic nonlinear characteristics of in vivo blood flow velocity and arteriolar diameter fluctuations.
Parthimos D, Osterloh K, Pries AR, Griffith TM,
Phys Med Biol,
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- Ca(2+), calpain and 3-phosphorylated phosphatidyl inositides; decision-making signals in neutrophils as potential targets for therapeutics.
Tian W, Dewitt S, Laffafian I, Hallett MB,
J Pharm Pharmacol,
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- Enhanced inhibition of the EDHF phenomenon by a phenyl methoxyalaninyl phosphoramidate derivative of dideoxyadenosine.
Griffith TM, Chaytor AT, Edwards DH, Daverio F, McGuigan C,
Br J Pharmacol,
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Bannister ML, Williams AJ,
Biochem Biophys Res Commun,
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- Ryanodine receptor oligomeric interaction: identification of a putative binding region.
Blayney LM, Zissimopoulos S, Ralph E, Abbot E, Matthews L, Lai FA,
J Biol Chem,
Volume 279,
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pp.14639-14648
- The cytosolic sperm factor that triggers Ca2+ oscillations and egg activation in mammals is a novel phospholipase C: PLC zeta
Swann K, Larman MG, Saunders CM, Lai FA,
Reproduction,
Volume 127,
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pp.431-439
- The cytosolic sperm factor that triggers Ca2+ oscillations and egg activation in mammals is a novel phospholipase C: PLCzeta.
Swann K, Larman MG, Saunders CM, Lai FA,
Reproduction,
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- Role of FKBP12.6 in hypoxia- and norepinephrine-induced Ca2+ release and contraction in pulmonary artery myocytes.
Zheng YM, Mei QB, Wang QS, Abdullaev I, Lai FA, Xin HB, Kotlikoff MI, Wang YX,
Cell Calcium,
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pp.345-355
- Removal of clustered positive charge from dihydropyridine receptor II-III loop peptide augments activation of ryanodine receptors.
Bannister ML, Williams AJ, Sitsapesan R,
Biochem Biophys Res Commun,
Volume 314,
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- Ca2+ syntillas, miniature Ca2+ release events in terminals of hypothalamic neurons, are increased in frequency by depolarization in the absence of Ca2+ influx.
De Crescenzo V, ZhuGe R, Velázquez-Marrero C, Lifshitz LM, Custer E, Carmichael J, Lai FA, Tuft RA, Fogarty KE, Lemos JR, Walsh JV,
J Neurosci,
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- Ca2+ influx shutdown during neutrophil apoptosis: importance and possible mechanism.
Ayub K, Hallett MB,
Immunology,
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- Molecular mechanisms underlying RyR2 (Ca2+ release channel) dysfunction in stress-induced VT
Thomas L, George C, Lai FA,
Biophysical Journal,
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George CH, Jundi H, Thomas NL, Lai FA,
Biophysical Journal,
Volume 86,
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- The interaction of ryanoids with individual ryanodine receptor channels.
Williams AJ, Tanna B,
Biol Res,
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- Residue Gln(4863) within a predicted transmembrane sequence of the Ca2+ release channel (ryanodine receptor) is critical for ryanodine interaction
Wang RW, Zhang L, Bolstad J, Diao N, Brown C, Ruest L, Welch W, Williams AJ, Chen SRW,
Journal Of Biological Chemistry,
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Stewart R, Zissimopoulos S, Lai FA,
Biochem J,
Volume 376,
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- Distinct hyperpolarizing and relaxant roles for gap junctions and endothelium-derived H2O2 in NO-independent relaxations of rabbit arteries.
Chaytor AT, Edwards DH, Bakker LM, Griffith TM,
Proc Natl Acad Sci U S A,
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- Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytes.
George CH, Higgs GV, Lai FA,
Circ Res,
Volume 93,
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- Dysregulated ryanodine receptors mediate cellular toxicity - Restoration of normal phenotype by FKBP12.6
George CH, Higgs GV, Mackrill JJ, Lai FA,
Journal Of Biological Chemistry,
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George CH, Higgs GV, Mackrill JJ, Lai FA,
J Biol Chem,
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- An anionic ryanoid, 10-O-succinoylryanodol, provides insights into the mechanisms governing the interaction of ryanoids and the subsequent altered function of ryanodine-receptor channels.
Tanna B, Welch W, Ruest L, Sutko JL, Williams AJ,
J Gen Physiol,
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- Shil'nikov homoclinic chaos is intimately related to type-III intermittency in isolated rabbit arteries: role of nitric oxide.
Parthimos D, Edwards DH, Griffith TM,
Phys Rev E Stat Nonlin Soft Matter Phys,
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Clin Exp Immunol,
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- The therapeutic potential of new insights into myocardial excitation-contraction coupling.
Scoote M, Poole-Wilson PA, Williams AJ,
Heart,
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- Ryanodine receptor type I and nicotinic acid adenine dinucleotide phosphate receptors mediate Ca2+ release from insulin-containing vesicles in living pancreatic beta-cells (MIN6).
Mitchell KJ, Lai FA, Rutter GA,
J Biol Chem,
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- Ryanodine receptor type I and nicotinic acid adenine dinucleotide phosphate receptors mediate Ca2+ release from insulin-containing vesicles in living pancreatic beta-cells (MIN6)
Mitchell KJ, Lai FA, Rutter GA,
Journal Of Biological Chemistry,
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- Ryanodine stores and calcium regulation in the inner segments of salamander rods and cones.
Krizaj D, Lai FA, Copenhagen DR,
J Physiol,
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George CH, Sorathia R, Bertrand BM, Lai FA,
Biochem J,
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Naka KK, Tweddel AC, Parthimos D, Henderson A, Goodfellow J, Frenneaux MP,
Am J Physiol Heart Circ Physiol,
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George CH, Lai FA,
Biophysical Journal,
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Rogers SA, George CH, Cox EV, Hazeel C, Lai FA,
Biophysical Journal,
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Morris MR, Dewitt S, Laffafian I, Hallett MB,
Methods Mol Biol,
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Hodges R, Laffafian I, Hallett MB,
Cell Biol Int,
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Methods Mol Biol,
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Cardiovasc Res,
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- Endogenous nitric oxide synthesis differentially modulates pressure-flow and pressure-conductance relationships in the internal and external carotid artery circulations of the rat.
Ujiie H, Edwards DH, Griffith TM,
Neurol Med Chir (Tokyo),
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Xiao B, Masumiya H, Jiang D, Wang R, Sei Y, Zhang L, Murayama T, Ogawa Y, Lai FA, Wagenknecht T, Chen SR,
J Biol Chem,
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- Sperm phospholipase Czeta from humans and cynomolgus monkeys triggers Ca2+ oscillations, activation and development of mouse oocytes.
Cox LJ, Larman MG, Saunders CM, Hashimoto K, Swann K, Lai FA,
Reproduction,
Volume 124,
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pp.611-623
- PLC zeta: a sperm-specific trigger of Ca(2+) oscillations in eggs and embryo development.
Saunders CM, Larman MG, Parrington J, Cox LJ, Royse J, Blayney LM, Swann K, Lai FA,
Development,
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West DJ, Smith EC, Williams AJ,
Biochem Biophys Res Commun,
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Brown SA, Bowen DJ, Hallett MB, Giddings JC, Collins PW,
Thromb Haemost,
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Hiscox S, Hallett MB, Morgan BP, van den Berg CW,
Biochem Biophys Res Commun,
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Frontiers In Bioscience,
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Griffith TM, Chaytor AT, Taylor HJ, Giddings BD, Edwards DH,
Proc Natl Acad Sci U S A,
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Febs Lett,
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Biophysical Journal,
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George CH, Lai A,
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Parthimos D, Edwards DH, Griffith TM,
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Sathish JG, Johnson KG, LeRoy FG, Fuller KJ, Hallett MB, Brennan P, Borysiewicz LK, Sims MJ, Matthews RJ,
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Mackrill JJ, O'Driscoll S, Lai FA, McCarthy TV,
Biochem Biophys Res Commun,
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Chaytor AT, Martin PE, Edwards DH, Griffith TM,
Am J Physiol Heart Circ Physiol,
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Taylor HJ, Chaytor AT, Edwards DH, Griffith TM,
Biochem Biophys Res Commun,
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Journal Of General Physiology,
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- A ryanodine fluorescent derivative reveals the presence of high-affinity ryanodine binding sites in the Golgi complex of rat sympathetic neurons, with possible functional roles in intracellular Ca(2+) signaling.
Cifuentes F, González CE, Fiordelisio T, Guerrero G, Lai FA, Hernández-Cruz A,
Cell Signal,
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Han ZG, Jiang WG, Hiscox S, Hallett MB, Isoai A, Mansel RE,
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Biochemical Journal,
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International Journal Of Oncology,
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Adebanjo OA, Shankar VS, Pazianas M, Simon BJ, Lai FA, Huang CL, Zaidi M,
Am J Physiol,
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Nature,
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Jiang WG, Hiscox S, Nakamura T, Hallett MB, Puntis MCA, Mansel RE,
Oncology Reports,
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Jiang WG, Hiscox S, Singhrao SK, Puntis MC, Nakamura T, Mansel RE, Hallett MB,
Biochem Biophys Res Commun,
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Jiang WG, Hiscox S, Hallett MB, Horrobin DF, Mansel RE, Puntis MC,
Cancer Res,
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J Cell Biol,
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Trends Pharmacol Sci,
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Jiang WG, Hiscox S, Horrobin DF, Hallett MB, Mansel RE, Puntis MC,
Anticancer Res,
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- COMPRESSION THERAPY REDUCES NEUTROPHIL PRIMING IN VENOUS ULCER DISEASE
SALAMAN R, HALLETT M, LANE I, HARDING K,
British Journal Of Surgery,
Volume 82,
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- GAMMA-LINOLENIC ACID UP-REGULATES E-CADHERIN EXPRESSION IN HUMAN CANCER-CELLS
JIANG W, HISCOX S, HALLETT M, HORROBIN D, PUNTIS M, MANSEL R,
British Journal Of Surgery,
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Laffafian I, Hallett MB,
J Cell Sci,
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Jiang WG, Hiscox S, Singhrao SK, Nakamura T, Puntis MC, Hallett MB,
Exp Cell Res,
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- NEW INSIGHTS INTO THE GATING MECHANISMS OF CARDIAC RYANODINE RECEPTORS REVEALED BY RAPID CHANGES IN LIGAND CONCENTRATION
SITSAPESAN R, MONTGOMERY R, WILLIAMS A,
Circulation Research,
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Biochem J,
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Hiscox S, Hallett MB, Puntis MC, Jiang WG,
Clin Exp Metastasis,
Volume 13,
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- DISTRIBUTION OF RYANODINE RECEPTOR ANTIBODY-BINDING IN FASCIOLA-HEPATICA
JANE S, BROWNLEE D, CHAD J, FAIRWEATHER I, TUNWELL R, LAI F, HOLDENDYE L, WALKER R,
Journal Of Physiology-London,
Volume 487P
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- A RYANODINE RECEPTOR-LIKE MOLECULE EXPRESSED IN THE OSTEOCLAST PLASMA-MEMBRANE FUNCTIONS IN EXTRACELLULAR CA2+
ZAIDI M, SHANKAR V, TUNWELL R, ADEBANJO O, MACKRILL J, PAZIANAS M, OCONNELL D, SIMON B, RIFKIN B, VENKITARAMAN A, HUANG C, LAI F,
Journal Of Clinical Investigation,
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- CAFFEINE-INDUCED ELEVATIONS OF INTRACELLULAR CA2+ IN RAT HIPPOCAMPAL-NEURONS AND IMMUNOHISTOLOGICAL EVIDENCE FOR THE RYR2 RYANODINE RECEPTOR ISOFORM
JANE S, PHENNA S, TUNWELL R, LAI F, CHAD J,
Journal Of Physiology-London,
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Immunology,
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Sitsapesan R, Montgomery RA, Williams AJ,
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- Complexity of chaotic vasomotion is insensitive to flow and pressure but can be regulated by external control.
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Am J Physiol,
Volume 269,
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- THE GATING OF THE SHEEP SKELETAL SARCOPLASMIC-RETICULUM CA2+-RELEASE CHANNEL IS REGULATED BY LUMINAL CA2+
SITSAPESAN R, WILLIAMS A,
Journal Of Membrane Biology,
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- Regulation of motility and invasion of cancer cells by human monocytic cells.
Jiang WG, Hiscox S, Hallett MB, Mansel RE, Puntis MC,
Anticancer Res,
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Biochim Biophys Acta,
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Poulsen JC, Caspersen C, Mathiasen D, East JM, Tunwell RE, Lai FA, Maeda N, Mikoshiba K, Treiman M,
Biochem J,
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van den Berg CW, Cinek T, Hallett MB, Horejsi V, Morgan BP,
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- INHIBITION OF HGF/SF-INDUCED TUMOR-CELL MEMBRANE RUFFLING BY CALCIUM SIGNALING
JIANG W, HISCOX S, PUNTIS M, HALLETT M,
British Journal Of Surgery,
Volume 82,
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- Cyclic ADP-ribose and related compounds activate sheep skeletal sarcoplasmic reticulum Ca2+ release channel.
Sitsapesan R, Williams AJ,
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Laffafian I, Davies EV, Campbell AK, Hallett MB,
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Jiang WG, Hiscox S, Hallett MB, Scott C, Horrobin DF, Puntis MC,
Br J Cancer,
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Biochemical And Biophysical Research Communications,
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Lloyds D, Brindle NP, Hallett MB,
Immunology,
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Br J Pharmacol,
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Pugh ND, Hutcheson IR, Edwards DH, Nossen JO, Karlsson JO, Griffith TM,
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Jiang WG, Puntis MC, Hallett MB,
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Percival AL, Williams AJ, Kenyon JL, Grinsell MM, Airey JA, Sutko JL,
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Lindsay AR, Tinker A, Williams AJ,
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Sitsapesan R, McGarry SJ, Williams AJ,
Circ Res,
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Davies EV, Williams BD, Whiston RJ, Cooper AM, Campbell AK, Hallett MB,
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- ANTIMOTILITY AND ANTI-INVASIVENESS EFFECTS OF INVASION-INHIBITING FACTOR-2 ON HUMAN COLONIC-CANCER CELLS
JIANG W, HISCOX S, HALLETT M, ISOAI A, PUNTIS M,
British Journal Of Surgery,
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- INDUCTION OF MOTILITY AND INVASION BY INTERLEUKIN-3 ON HUMAN COLONIC-CANCER CELLS
JIANG W, HISCOX S, HALLETT M, PUNTIS M,
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Whiston RJ, Hallett MB, Davies EV, Harding KG, Lane IF,
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Immunology,
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Xu L, Lai FA, Cohn A, Etter E, Guerrero A, Fay FS, Meissner G,
Proc Natl Acad Sci U S A,
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Jiang WG, Puntis MC, Hallett MB,
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Jiang WG, Hallett MB, Puntis MC,
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Morgan BP, van den Berg CW, Davies EV, Hallett MB, Horejsi V,
Eur J Immunol,
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Petersen M, Williams JD, Hallett MB,
Immunology,
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Lloyd Mills C, Hallett MB, McPherson MA, Dormer RL,
Biochem J,
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- PROBING THE MECHANISMS OF CALCIUM-RELEASE IN THE OSTEOCLAST USING CAFFEINE
ZAIDI M, SHANKAR V, ADEBANJO O, MORRIS E, MAKINDE V, BEVIS P, LATIF A, MOONGA B, LAI F, HUANG C, PAZIANAS M,
Journal Of Bone And Mineral Research,
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ZAIDI M, SHANKAR V, MAKINDE V, ADEBANJO O, MORRIS E, LATIF A, BEVIS P, MOONGA B, FINLAYSON C, SIMON B, PAZIANAS M, HUANG C, LAI F,
Journal Of Bone And Mineral Research,
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Jiang WG, Lloyds D, Puntis MC, Nakamura T, Hallett MB,
Clin Exp Metastasis,
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- Digoxin activates sarcoplasmic reticulum Ca(2+)-release channels: a possible role in cardiac inotropy.
McGarry SJ, Williams AJ,
Br J Pharmacol,
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- Monocyte-conditioned media possess a novel factor which increases motility of cancer cells.
Jiang WG, Puntis MC, Hallett MB,
Int J Cancer,
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- EXPRESSION OF RYANODINE RECEPTORS IN NONEXCITABLE TISSUES
TUNWELL R, LAI F,
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Lloyds D, Hallett MB,
Biochim Biophys Acta,
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Assender JW, Southgate KM, Hallett MB, Newby AC,
Biochem J,
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Lai FA, Dent M, Wickenden C, Xu L, Kumari G, Misra M, Lee HB, Sar M, Meissner G,
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Darling EM, Lai FA, Meissner G,
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- A MODEL FOR IONIC-CONDUCTION IN THE RYANODINE RECEPTOR CHANNEL OF SHEEP CARDIAC-MUSCLE SARCOPLASMIC-RETICULUM
TINKER A, LINDSAY A, WILLIAMS A,
Journal Of General Physiology,
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- Neutrophil priming by hepatocyte growth factor, a novel cytokine.
Jiang W, Puntis MC, Nakamura T, Hallett MB,
Immunology,
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- U937 cells stimulated with opsonised zymozan particles provide a convenient laboratory source of tumour necrosis factor alpha.
Jiang WG, Puntis MC, Hallett MB,
J Immunol Methods,
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Lai FA, Liu QY, Xu L, el-Hashem A, Kramarcy NR, Sealock R, Meissner G,
Am J Physiol,
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- Modification of gating of an airway epithelial chloride channel by 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB).
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- Impaired cyclic nucleotide-mediated vasorelaxation may contribute to closure of the human umbilical artery after birth.
Renowden S, Edwards DH, Griffith TM,
Br J Pharmacol,
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- Large tetraalkyl ammonium cations produce a reduced conductance state in the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel.
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- Elevations in cytosolic free Ca2+ are not required to trigger apoptosis in human leukaemia cells.
Lennon SV, Kilfeather SA, Hallett MB, Campbell AK, Cotter TG,
Clin Exp Immunol,
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Blayney LM, Gapper PW, Newby AC,
Biochem J,
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- REACTIVE OXYGEN SPECIES MODIFY THE STRUCTURE AND FUNCTION OF THE CARDIAC SARCOPLASMIC-RETICULUM CALCIUM-RELEASE CHANNEL
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SITSAPESAN R, WILLIAMS A,
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- INCREASED PRODUCTION OF OXYGEN RADICALS BY CIRCULATING MONOCYTES IN INFLAMMATORY BOWEL-DISEASE - EVIDENCE OF ACTIVATION
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- A MICROANGIOGRAPHIC STUDY OF VASCULAR-RESPONSES IN THE ISOLATED RAT-KIDNEY
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Fry DL, Jundi H, Thomas NL, Lai FA, George CH,
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Saunders CM, Swann K, Lai FA,
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George CH,
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pp.985-985
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Griffith TM, Parthimos D, Edwards DH,
Proceedings Of The Institution Of Mechanical Engineers Part C-Journal Of Mechanical Engineering Science,
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pp.367-383
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Jones JL, Reynolds D, Lai FA, Blayney L,
Journal Of Molecular And Cellular Cardiology,
Volume 39,
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pp.182-183
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Thomas L, George C, Lai A,
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pp.308A-309A
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Ranatunga KM, Moreno-King TM, Tanna B, Wang RW, Chen SRW, Ruest L, Welch W, Williams AJ,
Biophysical Journal,
Volume 88,
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pp.269A-270A
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Zissimopoulos S, White J, Cheung I, Stewart R, Lai FA,
Biophysical Journal,
Volume 88,
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pp.270A-270A
- Analysis of RyR-FKBP interaction using surface plasmon resonance: effect of modulators of channel opening and closing
Jones JL, Reynolds D, Zissimopoulos S, Lai FA, Blayney L,
Biophysical Journal,
Volume 88,
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pp.309A-309A
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Xiao BL, Jiang MT, Zhao MC, Yang DM, Sutherland C, Lai FA, Walsh MP, Cheng HP, Chen SRW,
Biophysical Journal,
Volume 88,
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pp.188A-188A
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George CH, Walters N, Thomas NL, Yeung WY, Reynolds DF, Lai FA,
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- Sarcolemmal L-type calcium channel : Intracellular calcium release channel (ryanodine receptor) stoichiometry is reduced in pressure overload heart failure but not in chronic catecholaminergic exposure.
Scoote M, MacLeod KT, Harding SE, Kingsbury MP, Turner MA, Sheridan DJ, Williams AJ,
Biophysical Journal,
Volume 88,
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- Mutations of negatively charged residues in the putative pore region of RyR2 affect ion translocation
Mead FC, Wang RW, Rheault S, Welch W, Chen SRW, Williams AJ,
Biophysical Journal,
Volume 88,
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pp.270A-270A
- Effects of the mutation E4830A in the putative selectivity filter region of mouse RyR2 on the interaction of both permeant and impermeant cations
Tanna B, Rheault S, Welch W, Wang RW, Chen SRW, Williams AJ,
Biophysical Journal,
Volume 88,
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pp.270A-270A
- The interaction of the large organic cation, tetrabutylammonium, differs between ryanoid-modified states in mouse RyR2.
Ranatunga KM, Ruest L, Chen W, Welch W, Williams AJ,
Biophysical Journal,
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- Antioxidant activity of 5-MTHF and BH4 can preserve EDHF-type responses by modulating electrotonic signalling
Edwards DH, Chaytor AT, Bakker LM, Griffith TM,
Journal Of Vascular Research,
Volume 42
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pp.84-84
- Functional characteristics of the cardiac ryanodine receptor in an experimental model of heart failure
Scoote M, Harding SE, MacLeod KT, Kingsbury MP, Sheridan DJ, Williams AJ,
Journal Of Molecular And Cellular Cardiology,
Volume 36,
5
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pp.757-758
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Scoote M, Harding SE, MacLeod KT, Kingsbury MP, Sheridan DJ, Williams AJ,
Journal Of Molecular And Cellular Cardiology,
Volume 36,
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pp.732-732
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Scoote M, George CH, Lai FA, Williams AJ,
Biophysical Journal,
Volume 86,
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pp.402A-403A
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George CH, Jundi H, Thomas NL, Lai FA,
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1
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pp.49A-50A
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Welch W, Rheault S, West D, Williams A,
Biophysical Journal,
Volume 86,
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pp.402A-402A
- The phytoestrogen genistein inhibits calcium spark production and ryanodine binding in adult male ventricular myocytes
Liew R, Scoote M, Stagg MA, Collins P, Williams AJ, MacLeod KT,
Biophysical Journal,
Volume 86,
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pp.111A-111A
- Mechanisms underlying the effects of varying ionic strength on neomycin block of RyR2
Mead FC, Williams AJ,
Biophysical Journal,
Volume 86,
1
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pp.401A-401A
- Interactions of biotinylated ryanoids with single RyR2 channels.
Ranatunga KM, Tanna B, Chohan S, Kipke T, Ruest L, Sutko J, Welch W, Williams AJ,
Biophysical Journal,
Volume 86,
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pp.402A-402A
- A putative interaction site of ryanodine receptor coupling
Blayney L, Zissimopoulos S, Lai FA,
Biophysical Journal,
Volume 86,
1
(January 2004)
pp.112A-112A
- Interaction of the cardiac ryanodine receptor with the SNARE-associated protein, snapin
Zissimopoulos S, Lai FA,
Biophysical Journal,
Volume 86,
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pp.233A-233A
- What anchors PLC-zeta to membranes? A unique cluster of basic residues in the catalytic linker region may interact with acidic lipids in membranes.
Pallavi P, Lai FA, Wang JY, Murray D, McLaughlin S,
Biophysical Journal,
Volume 86,
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pp.377A-377A
- The functional effects of secondary ryanoids on single ryanoid-modified sheep RyR2 channels
Tanna B, Welch W, Ruest L, Sutko JL, Williams AJ,
Biophysical Journal,
Volume 86,
1
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pp.402A-402A
- Molecular mechanisms underlying RyR2 (Ca2+ release channel) dysfunction in stress-induced VT
Thomas L, George C, Lai FA,
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Volume 86,
1
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- Transcriptional alterations mediated via dysregulated human cardiac ryanodine receptor (hRyR2).
George CH, Lai FA,
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Volume 84,
2
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pp.390A-390A
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Blayney L, Zissimopoulos S, Ralph E, Lai FA,
Biophysical Journal,
Volume 84,
2
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pp.111A-111A
- Expression of human RyR2 splice variants
Rogers SA, George CH, Cox EV, Hazeel C, Lai FA,
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2
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pp.64A-64A
- Immature circulating neutrophils in sepsis have impaired phagocytosis and aberrant Ca2+signalling.
Morris MR, Hallett MB, Taneja R,
Intensive Care Medicine,
Volume 28
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pp.S16-S16
- The binding of [H-3]-ryanodine to RyR2 is influenced by channel blocking cations
Tanna B, West DJ, Williams AJ,
Biophysical Journal,
Volume 82,
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pp.74A-75A
- The interaction of a negatively charged ryanoid with RyR2 is voltage dependent
Tanna B, Welch W, Sutko J, Ruest L, Williams AJ,
Biophysical Journal,
Volume 82,
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pp.74A-74A
- Neomycin block of RyR2 is modified by changes in ionic strength
Mead FC, Williams AJ,
Biophysical Journal,
Volume 82,
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pp.75A-75A
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Parthimos D, Edwards DH, Griffith TM,
, Siena, Italy
Federation Of European Physiological Societies
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Edited by Universita' degli Studi di Milano
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Saftenku E, Williams AJ, Sitsapesan R,
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Biophys J,
Volume 80,
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pp.2727-2741
- Recognition force microscopy/spectroscopy of ion channels: applications to the skeletal muscle Ca2+ release channel (RYR1).
Kada G, Blayney L, Jeyakumar LH, Kienberger F, Pastushenko VP, Fleischer S, Schindler H, Lai FA, Hinterdorfer P,
, Netherlands
Ultramicroscopy,
Volume 86,
1-2
(January 2001)
pp.129-137
- Heterogeneity of EDIT'-type relaxations of rabbit and rat arteries analysed with peptides homologous to the extracellular loops of connexins 37, 40 and 43
Griffith TM, Chaytor AT, Berman RS, Edwards DH,
Edhf 2000
(2001)
pp.62-74
- Voltage-dependent gating in sheep cardiac ryanodine receptor channels
Bannister ML, Williams AJ, Sitsapesan R,
Journal Of Physiology-London,
Volume 527
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pp.83P-83P
- Evidence for luminal Ca2+-binding sites on the sheep cardiac ryanodine receptor complex
Ching LL, Williams AJ, Sitsapesan R,
Journal Of Physiology-London,
Volume 527
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pp.82P-82P
- Excess noise in the ryanoid-modified conductance state of the RyR2 channel
Williams AJ, Haji N, Tanna B, Welch W, Ruest L, Sutko J,
Biophysical Journal,
Volume 78,
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pp.191A-191A
- Luminal trypsin alters the response of the sheep cardiac RyR to luminal Ca2+
Ching LL, Williams AJ, Sitsapesan R,
Biophysical Journal,
Volume 78,
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pp.191A-191A
- Ryanoid-induced re-location of a blocking site in the RyR2 channel.
Tanna B, Ruest L, Sutko JL, Welch W, Williams AJ,
Biophysical Journal,
Volume 78,
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pp.191A-191A
- Ca2+-dependence of low and high activity levels of cardiac ryanodine receptor channels.
Saftenku E, Williams AJ, Sitsapesan R,
Biophysical Journal,
Volume 78,
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Mead FC, Williams AJ,
Biophysical Journal,
Volume 78,
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pp.191A-191A
- Exploring the Ca2+ sensitivity of modal gating of the cardiac Ca2+-release channel results in new Markovian models
Saftenku EE, Williams AJ, Sitsapesan R,
Neurophysiology,
Volume 32,
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pp.127-128
- Occupation of the ryanodine binding site on RyR modifies channel block by TEA.
Tanna B, Ruest L, Welch W, Sutko J, Williams AJ,
Biophysical Journal,
Volume 76,
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- AMP is an agonist with low efficacy at the ATP sites on the sheep cardiac ryanodine receptor
Ching LL, Williams AJ, Sitsapesan R,
Biophysical Journal,
Volume 76,
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pp.A376-A376
- Characterisation of the interaction of ryanodol with the Heliothis virescens ryanodine receptor
Scott-Ward TS, Williams AJ, Windass JD, Dunbar SJ,
Biophysical Journal,
Volume 76,
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pp.A377-A377
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Tanna B, Ruest L, Welch W, Sutko J, Williams AJ,
Biophysical Journal,
Volume 76,
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Griffith TM, Edwards DH,
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Proc Inst Mech Eng H,
Volume 213,
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Evans WH, Ahmad S, Diez J, George CH, Kendall JM, Martin PEM,
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Morris MR, Pereira MM, Hallett MB, McPherson MA, Dormer RL,
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Ching LL, Williams AJ, Sitsapesan R,
Journal Of Physiology-London,
Volume 509P
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pp.144P-145P
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Kermode H, Williams AJ, Sitsapesan R,
Biophysical Journal,
Volume 74,
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Tanna B, Ruest L, Welch W, Sutko J, Williams AJ,
Biophysical Journal,
Volume 74,
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Biophysical Journal,
Volume 74,
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George CH, Kendall JM, Campbell AK, Martin PEM, Evans WH,
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Martin PEM, Castro C, George CH, Capel J, Campbell AK, Revilla A, Barrio LC, Evans WH,
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Griffith T, Chaytor A, Evans W, Edwards D,
20th European Conference On Microcirculation
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- Block of the ryanodine-modified cardiac sarcoplasmic reticulum (SR) Ca2+ release channel by ShakerB K+ channel N-type inactivation peptides is influenced by the net charge of the peptide.
Mead F, Sullivan D, Williams AJ,
Journal Of Physiology-London,
Volume 504P
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Kermode HE, Williams AJ, Sitsapesan R,
Journal Of Physiology-London,
Volume 504P
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Tanna B, Ruest L, Welch W, Sutko J, Williams AJ,
Journal Of Physiology-London,
Volume 504P
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pp.P163-P164
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Zhang JJ, Sitsapesan R, Williams AJ,
Journal Of Physiology-London,
Volume 504P
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Williams AJ, Ruest L, Welch W, Sutko J,
Biophysical Journal,
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Williams AJ, Ruest L, Welch W, Sutko J,
Journal Of Physiology-London,
Volume 499P
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Biophysical Journal,
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Biophysical Journal,
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Biophysical Journal,
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Journal Of Vascular Research,
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