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Research at the Institute of Psychological Medicine & Clinical Neurosciences

Our research is tackling some of the major psychiatric and neurological disorders.

Our research is aimed at understanding the fundamental mechanisms underlying major psychiatric and neurological disorders. There are programmes of work on schizophrenia, bipolar disorder, depression in children and adolescents, ADHD, Alzheimer's disease, Parkinson's disease, Huntington's disease and epilepsy among others. There is a major focus on genetics and genomics but also interest in brain imaging, epidemiology, animal models and cell biology. There is a programme of collaborative research with Psychology, and work on psycho-education, health services research, and public engagement.

Research themes

Work in the Institute is coordinated across several core related themes:

  • Psychosis and Major Affective Disorders
  • Neurodegenerative Disorders
  • Developmental Disorders
  • Biostatistics & Bioinformatics
  • National Centre for Mental Health
  • Neuropsychiatric Imaging
  • Animal and Cellular Models
  • Welsh Centre for Learning Disabilities
  • Forensic Psychiatry

Key research staff

Recent funding awards

  • Defining genetic, polygenic and environmental risk for Alzheimer's disease using multiply powerful cohorts, forcussed epigenetics and stem cell. Prof J Williams , Dr V Escott-Price , Dr D Harold. Medical Research Council, 01/01/2014 - 31/12/2016, £1,242,935.00
  • Taking imaging into the therapeutic domain: self-regulation of brain systems for mental disorders. Prof DEJ Linden. Brain Innovation BV, 01/11/2013 - 31/10/2017, £1,056,470.00
  • DEFINE - Defining endophenotypes from integrated neuroscience. Prof MJ Owen , Prof DK Jones , Prof DEJ Linden , Prof LS Wilkinson , Prof V Crunelli , Prof AJ Harwood. Wellcome Trust, 01/07/2013 - 30/06/2018, £5,234,843
  • ANti-psychotic drug Reduction in primary care for adults with learning disabilities (ANDREA-LD): A randomised double-blind placebo controlled trial. Prof MP Kerr , Prof DJ Felce , Mr D Gillespie , Prof K Hood , Miss RL Mcnamara , Dr AK Thapar , Dr FC Wood. National Institute for Health Research, 01/04/2013 - 30/06/2016, £1,758,003

Publications

  • Journal article CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1.
    Rees E, Walters JT, Chambert KD, O'Dushlaine C, Szatkiewicz J, Richards AL, Georgieva L, Mahoney-Davies G, Legge SE, Moran JL, Genovese G, Levinson D, Morris DW, Cormican P, Kendler KS, O'Neill FA, Riley B, Gill M, Corvin A, Wellcome Trust Case Control Consortium None, Sklar P, Hultman C, Pato C, Pato M, Sullivan PF, Gejman PV, McCarroll SA, O'Donovan MC, Owen MJ, Kirov G, Hum Mol Genet, Volume 23, 6 (March 2014) pp.1669-1676
  • Journal article The penetrance of copy number variations for schizophrenia and developmental delay.
    Kirov G, Rees E, Walters JT, Escott-Price V, Georgieva L, Richards AL, Chambert KD, Davies G, Legge SE, Moran JL, McCarroll SA, O'Donovan MC, Owen MJ, Biol Psychiatry, Volume 75, 5 (March 2014) pp.378-385
  • Journal article De novo mutations in schizophrenia implicate synaptic networks.
    Fromer M, Pocklington AJ, Kavanagh DH, Williams HJ, Dwyer S, Gormley P, Georgieva L, Rees E, Palta P, Ruderfer DM, Carrera N, Humphreys I, Johnson JS, Roussos P, Barker DD, Banks E, Milanova V, Grant SG, Hannon E, Rose SA, Chambert K, Mahajan M, Scolnick EM, Moran JL, Kirov G, Palotie A, McCarroll SA, Holmans P, Sklar P, Owen MJ, Purcell SM, O'Donovan MC, Nature, Volume 506, 7487 (February 2014) pp.179-184