Research at the Institute of Psychological Medicine & Clinical Neurosciences
Our research is tackling some of the major psychiatric and neurological disorders.
Our research is aimed at understanding the fundamental mechanisms underlying major psychiatric and neurological disorders. There are programmes of work on schizophrenia, bipolar disorder, depression in children and adolescents, ADHD, Alzheimer's disease, Parkinson's disease, Huntington's disease and epilepsy among others. There is a major focus on genetics and genomics but also interest in brain imaging, epidemiology, animal models and cell biology. There is a programme of collaborative research with Psychology, and work on psycho-education, health services research, and public engagement.
Work in the Institute is coordinated across several core related themes:
Recent funding awards
- Defining genetic, polygenic and environmental risk for Alzheimer's disease using multiply powerful cohorts, forcussed epigenetics and stem cell. Prof J Williams , Dr V Escott-Price , Dr D Harold. Medical Research Council, 01/01/2014 - 31/12/2016, £1,242,935.00
- Taking imaging into the therapeutic domain: self-regulation of brain systems for mental disorders. Prof DEJ Linden. Brain Innovation BV, 01/11/2013 - 31/10/2017, £1,056,470.00
- DEFINE - Defining endophenotypes from integrated neuroscience. Prof MJ Owen , Prof DK Jones , Prof DEJ Linden , Prof LS Wilkinson , Prof V Crunelli , Prof AJ Harwood. Wellcome Trust, 01/07/2013 - 30/06/2018, £5,234,843
- ANti-psychotic drug Reduction in primary care for adults with learning disabilities (ANDREA-LD): A randomised double-blind placebo controlled trial. Prof MP Kerr , Prof DJ Felce , Mr D Gillespie , Prof K Hood , Miss RL Mcnamara , Dr AK Thapar , Dr FC Wood. National Institute for Health Research, 01/04/2013 - 30/06/2016, £1,758,003
- Genetic risk for attention-deficit/hyperactivity disorder contributes to neurodevelopmental traits in the general population. Biol Psychiatry, Volume 76, 8 October 2014 pp.664-671
- CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1. Hum Mol Genet, Volume 23, 6 March 2014 pp.1669-1676
- The penetrance of copy number variations for schizophrenia and developmental delay. Biol Psychiatry, Volume 75, 5 March 2014 pp.378-385
- Archive of publications (294 items)