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Research at the Institute of Psychological Medicine & Clinical Neurosciences

Our research is tackling some of the major psychiatric and neurological disorders.

Our research is aimed at understanding the fundamental mechanisms underlying major psychiatric and neurological disorders. There are programmes of work on schizophrenia, bipolar disorder, depression in children and adolescents, ADHD, Alzheimer's disease, Parkinson's disease, Huntington's disease and epilepsy among others. There is a major focus on genetics and genomics but also interest in brain imaging, epidemiology, animal models and cell biology. There is a programme of collaborative research with Psychology, and work on psycho-education, health services research, and public engagement.

Research themes

Work in the Institute is coordinated across several core related themes:

  • Psychosis and Major Affective Disorders Our work aims to understand the genetic and environmental factors involved in the major psychotic and mood disorders (including schizophrenia, bipolar disorder and depression).
  • Neurodegenerative Disorders Our aims are to understand some of the causes of different forms of neurodegeneration including Alzheimer’s, Parkinson’s, Huntington’s diseases and multiple sclerosis.
  • Developmental Disorders (Child Psychiatry) The aims of the section are to conduct and promote high quality research and teaching in Child & Adolescent Psychiatry under the guidance of Prof Anita Thapar.
  • Biostatistics & Bioinformatics Our work focuses on the analysis of large volumes of biological data to help understand the causes of mental-health related diseases.
  • National Centre for Mental Health The National Centre’s work will improve life for patients through research and sharing knowledge and best practice.
  • Neuropsychiatric Imaging The neuropsychiatric imaging group investigates the effects of genes (and their interaction with the environment) on brain structure and function and on behaviour.
  • Animal and Cellular Models Our work aims to uncover the roles of specific genes in human behaviour and brain function.
  • Welsh Centre for Learning Disabilities The Welsh Centre for Learning Disabilities brings together a range of expertise in clinical practice, research and teaching associated with the lives of people with learning disabilities
  • Forensic Psychiatry Forensic psychiatry is a medical specialty based on knowledge of relationships between mental disorder, antisocial behaviour and offending, and of relevant law, criminal and civil justice systems.

Key research staff

Recent funding awards

  • Defining genetic, polygenic and environmental risk for Alzheimer's disease using multiply powerful cohorts, forcussed epigenetics and stem cell. Prof J Williams , Dr V Escott-Price , Dr D Harold. Medical Research Council, 01/01/2014 - 31/12/2016, £1,242,935.00
  • Taking imaging into the therapeutic domain: self-regulation of brain systems for mental disorders. Prof DEJ Linden. Brain Innovation BV, 01/11/2013 - 31/10/2017, £1,056,470.00
  • DEFINE - Defining endophenotypes from integrated neuroscience. Prof MJ Owen , Prof DK Jones , Prof DEJ Linden , Prof LS Wilkinson , Prof V Crunelli , Prof AJ Harwood. Wellcome Trust, 01/07/2013 - 30/06/2018, £5,234,843
  • ANti-psychotic drug Reduction in primary care for adults with learning disabilities (ANDREA-LD): A randomised double-blind placebo controlled trial. Prof MP Kerr , Prof DJ Felce , Mr D Gillespie , Prof K Hood , Miss RL Mcnamara , Dr AK Thapar , Dr FC Wood. National Institute for Health Research, 01/04/2013 - 30/06/2016, £1,758,003

Publications