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Project Name

Resistance in Gram-Negative Organisms: Studying Intervention Strategies (R-GNOSIS)




7th Framework Programme (FP7)
FP7 Cooperation Theme 1-Health- Large Scale Integrating Project

Principal Investigator

Primary Care Work Package Team:
Prof Kerry Hood , SEWTU, Primary Care and Public Health
Dr Nick Francis , WSPCR, Primary Care and Public Health
Dr Micaela Gal , WSPCR, Primary Care and Public Health
Prof Theo Verheij, Utrecht University
Prof Paul Little, Southampton University
Overall study coordinator: Prof Marc Bonten, University Medical Centre Utrecht.


R-GNOSIS (Resistance in Gram-Negative Organisms: Studying Intervention Strategies) combines 5 international clinical intervention studies, all supported by highly innovative microbiology and mathematical modelling, to determine - in the most relevant patient populations - the efficacy and effectiveness of cutting-edge interventions to reduce acquisition, carriage, infection and spread of Multi-Drug Resistant Gram-negative Bacteria (MDR-GNB). The studies and analyses proposed in R-GNOSIS will generate a step-change in identifying evidence-based preventive measures and clinical guidance for primary care and hospital-based physicians, as well as health-care authorities, to combat the spread and impact of the unprecedented rise of infections caused by MDR-GNB in Europe.

POETIC (Point Of carE testing for urinary Tract Infection in primary Care) is part of R-GNOSIS and is led by Professor Chris Butler. POETIC is an evaluation of a novel Point of Care Test (POCT) guided urinary tract infection (UTI) management strategy for use in adult women presenting in primary care with suspected uncomplicated UTI. The POCT will provide clinicians, at the point of care, within 24 hours, with a diagnosis of bacterial UTI and resistance profiles of any identified pathogen to the antibiotics most commonly used for UTI in primary care. The study will determine whether or not this information aids clinicians to more appropriately prescribe antibiotics for uncomplicated UTI’s (i.e. avoid the use of antibiotics for women where no bacterial infection is identified, and where a bacterial infection is identified, to ensure the narrowest spectrum antibiotic is prescribed appropriate to the sensitivity of the infecting organisms). Urine samples will also be sent for culture in local microbiology laboratories, and the appropriateness of the decision whether or what antibiotic to prescribe, will be assessed in comparison to the results obtained from laboratory (as opposed to POCT) culture. The study is being carried out in 4 European networks: Wales, England, Netherlands and Spain, and is divided into four stages as outlined below.

Start date

January 2012

End date

December 2016

Further information

R-GNOSIS study website:

POETIC study website: