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Genomics to combat Resistance against Antibiotics in Community-acquired LRTI in Europe


€11.5 Million EU


European Commission (6th Framework Programme)

Principal Investigator


Cardiff: Prof Kerry Hood , Mrs Jacqueline Nuttall , Dr Lucy Brookes-Howell , Dr Giles Greene , Mrs Jacqueline Swain .

Partner institutions: Universiteit Antwerpen (Belgium), Finnish Office for Health Care Technology Assessment (Finland), Diakoniekrankenhaus Rotenburg (Germany), DRC Ltd, Balatonfured (Hungary), University of Milan (Italy), Universitair Medisch Centrum Utrecht (The Netherlands), University of Tromsö (Norway), Medical University of Lodz (Poland), Centro atencio primaria example, Barcelona; Hospital di Mataro (Spain), Research Associates & Consultants, Bratislava (Slovakia), Swedish Institute for Infectious Disease Control, Stockholm (Sweden), University of Southampton (UK).

Lay summary

GRACE is a Network of Excellence focusing on the complex and controversial field of community-acquired lower respiratory tract infections (CA-LRTI), which is one of the leading reasons for seeking medical care.

The overall objective of GRACE is to combat antimicrobial resistance through integrating centres of research excellence and using genomics to most appropriately investigate and manage community-acquired LRTI.

GRACE also aims to establish a durable European primary care network (with close links to local hospitals and laboratories) to meet the specific objectives and to create a clinical platform for ongoing epidemiological and intervention studies in the field of community-acquired LRTI (GRACE-PAT). There are 14 Primary Care Networks taking part in GRACE from 12 Countries in Europe.

This research programme has been divided into 4 platforms (GRACE-COMIT, GRACE-TECH, GRACE-PAT, GRACE-EDUT) and 12 workpackages (WP1 – WP12). For more information visit the GRACE web site.

Cardiff University are leading on WP8, which falls within the patient platform of GRACE, GRACE-PAT and has three aspects;
[1] GRACE-01: Observational Study. This Study aims to describe the presentation, diagnosis, investigation, management and outcomes for people with cough / chest infection
[2] GRACE-02: Qualitative Study. This Study aims to achieve a deep understanding of the reasons underlying the quantitative description of variation in presentation, investigation, management and outcomes.
[3] Definitions Development: This involves developing definitions relevant to community-acquired LRTI on which to base later observational, intervention and modelling studies.

Start date

Mar 2006

End date

Aug 2011

Related publications

PLOS One Research Article: Are Patient Views about Antibiotics Related to Clinician Perceptions, Management and Outcome? A Multi-Country Study in Outpatients with Acute Cough. Published online: 26 October 2013.

Further information

on SEWTU webpages
GRACE-INTRO - Genomics to combat Resistance against Antibiotics for Community acquired lower respiratory tract infection (LRTI) in Europe: INternet Training for Reducing antibiOtic use trial.

News coverage

Antibiotic prescribing should be standardized across Europe to help tackle resistance. News Medical, 24 June 2009.

Standardise antibiotic use. Cardiff News Centre, 24 Jun 2009.

Call for Antibiotic Prescribing to be Standardized Across Europe. Med India, 24 Jun 2009.

Stop prescribing antibiotics for coughs, GPs in Europe told. OnMedica, 24 Jun 2009.

Standardise antibiotics, say experts. Irish Health, 25 Jun 2009.

Antibiotic prescribing "should be standardised across Europe". Nursing in Practice, 24 Jun 2009.

Antibiotic prescribing for LRTI 'could be halved'. Pulse, 26 Jun 2009.