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Dr Aled Clayton

Senior Lecturer, Institute of Cancer & Genetics

Research overview

The group's aims are to better understand the complex roles of exosomes in cancer.  Exosomes are nano-metre sized vesicles, produced in abundance by malignant cells.  Their physiological functions remain incompletely understood.

Data from our group demonstrate exosomes as a mechanism for immune evasion, as cancer exosomes can negatively regulate T cell and NK cell functions.  Cancer exosomes may also exert some influences within the microenvironment which also assist disease progression.

The molecular mechanisms underlying these effects are being examined, to aid in the design of future therapies targeted to attenuating these and other exosomal functions.

Recent key publications