Dr Aled Clayton
Senior Lecturer, Institute of Cancer & Genetics
The group's aims are to better understand the complex roles of exosomes in cancer. Exosomes are nano-metre sized vesicles, produced in abundance by malignant cells. Their physiological functions remain incompletely understood.
Data from our group demonstrate exosomes as a mechanism for immune evasion, as cancer exosomes can negatively regulate T cell and NK cell functions. Cancer exosomes may also exert some influences within the microenvironment which also assist disease progression.
The molecular mechanisms underlying these effects are being examined, to aid in the design of future therapies targeted to attenuating these and other exosomal functions.
Selected key publications
- Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation.
Kalra H, Simpson RJ, Ji H, Aikawa E, Altevogt P, Askenase P, Bond VC, Borràs FE, Breakefield X, Budnik V, Buzas E, Camussi G, Clayton A, Cocucci E, Falcon-Perez JM, Gabrielsson S, Gho YS, Gupta D, Harsha HC, Hendrix A, Hill AF, Inal JM, Jenster G, Krämer-Albers EM, Lim SK, Llorente A, Lötvall J, Marcilla A, Mincheva-Nilsson L, Nazarenko I, Nieuwland R, Nolte-'t Hoen EN, Pandey A, Patel T, Piper MG, Pluchino S, Prasad TS, Rajendran L, Raposo G, Record M, Reid GE, Sánchez-Madrid F, Schiffelers RM, Siljander P, Stensballe A, Stoorvogel W, Taylor D, Thery C, Valadi H, van Balkom BW, Vázquez J, Vidal M, Wauben MH, Yáñez-Mó M, Zoeller M, Mathivanan S, Plos Biol, Volume 10, 12 (2012) p. e1001450
- Cancer exosomes express CD39 and CD73, which suppress T cells through adenosine production.
Clayton A, Al-Taei S, Webber J, Mason MD, Tabi Z, J Immunol, Volume 187, 2 (July 2011) pp.676-683
- Cancer exosomes trigger fibroblast to myofibroblast differentiation.
Webber J, Steadman R, Mason MD, Tabi Z, Clayton A, Cancer Res, Volume 70, 23 (December 2010) pp.9621-9630
- Proteomics analysis of bladder cancer exosomes.
Welton JL, Khanna S, Giles PJ, Brennan P, Brewis IA, Staffurth J, Mason MD, Clayton A, Mol Cell Proteomics, Volume 9, 6 (June 2010) pp.1324-1338
- Exosomes in tumour immunity
Clayton A, Mason MD, Current Oncology, Volume 16, 3 (June 2009) pp.187-190
- Human tumor-derived exosomes down-modulate NKG2D expression.
Clayton A, Mitchell JP, Court J, Linnane S, Mason MD, Tabi Z, J Immunol, Volume 180, 11 (June 2008) pp.7249-7258