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Dr Aled Clayton

Senior Lecturer, Institute of Cancer & Genetics

Research overview

The group aims to better understand the complex roles of exosomes in cancer. Exosomes are nano-metre sized vesicles, produced in abundance by malignant cells. Their physiological functions remain incompletely understood.

Data from our group demonstrate exosomes as a mechanism for immune evasion, as cancer exosomes can negatively regulate T cell and NK cell functions.

Cancer exosomes can also exert other influences within the microenvironment, such as promotion of activated stroma, which also assist disease progression. The molecular mechanisms underlying these effects are being examined, to aid in the design of future therapies targeted to attenuating these and other exosomal functions.

There is also potential utility in the vesicles acting as disease biomarkers. Because they are present in biological fluids such as blood, urine and CSF; isolation of vesicles from such fluids provides access to a particular set of molecular markers (proteins, lipids and RNA) that may be related to disease processes.

Funding Bodies

Other responsibilities

Recent key publications

  • EVpedia: a community web portal for extracellular vesicles research. Bioinformatics, Volume 31, 6 March 2015 pp.933-939 Kim DK, Lee J, Kim SR, Choi DS, Yoon YJ, Kim JH, Go G, Nhung D, Hong K, Jang SC, Kim SH, Park KS, Kim OY, Park HT, Seo JH, Aikawa E, Baj-Krzyworzeka M, van Balkom BW, Belting M, Blanc L, Bond V, Bongiovanni A, Borràs FE, Buée L, Buzás EI, Cheng L, Clayton A, Cocucci E, Dela Cruz CS, Desiderio DM, Di Vizio D, Ekström K, Falcon-Perez JM, Gardiner C, Giebel B, Greening DW, Gross JC, Gupta D, Hendrix A, Hill AF, Hill MM, Nolte-'t Hoen E, Hwang DOW, Inal J, Jagannadham MV, Jayachandran M, Jee YK, Jørgensen M, Kim KP, Kim YK, Kislinger T, Lässer C, Lee DS, Lee H, van Leeuwen J, Lener T, Liu ML, Lötvall J, Marcilla A, Mathivanan S, Möller A, Morhayim J, Mullier F, Nazarenko I, Nieuwland R, Nunes DN, Pang K, Park J, Patel T, Pocsfalvi G, Del Portillo H, Putz U, Ramirez MI, Rodrigues ML, Roh TY, Royo F, Sahoo S, Schiffelers R, Sharma S, Siljander P, Simpson RJ, Soekmadji C, Stahl P, Stensballe A, Stępień E, Tahara H, Trummer A, Valadi H, Vella LJ, Wai SN, Witwer K, Yáñez-Mó M, Youn H, Zeidler R, Gho YS
  • Cancer exosomes trigger mesenchymal stem cell differentiation into pro-angiogenic and pro-invasive myofibroblasts. Oncotarget, Volume 6, 2 January 2015 pp.715-731 Chowdhury R, Webber JP, Gurney M, Mason MD, Tabi Z, Clayton A
  • Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes. Oncogene, Volume 34, 3 January 2015 pp.290-302 Webber JP, Spary LK, Sanders AJ, Chowdhury R, Jiang WG, Steadman R, Wymant J, Jones AT, Kynaston H, Mason MD, Tabi Z, Clayton A
  • Enhancement of T cell responses as a result of synergy between lower doses of radiation and T cell stimulation. J Immunol, Volume 192, 7 April 2014 pp.3101-3110 Spary LK, Al-Taei S, Salimu J, Cook AD, Ager A, Watson HA, Clayton A, Staffurth J, Mason MD, Tabi Z
  • Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscan™) platform. Mol Cell Proteomics, Volume 13, 4 April 2014 pp.1050-1064 Webber J, Stone TC, Katilius E, Smith BC, Gordon B, Mason MD, Tabi Z, Brewis IA, Clayton A
  • Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation. Plos Biol, Volume 10, 12 2012 p. e1001450 Kalra H, Simpson RJ, Ji H, Aikawa E, Altevogt P, Askenase P, Bond VC, Borràs FE, Breakefield X, Budnik V, Buzas E, Camussi G, Clayton A, Cocucci E, Falcon-Perez JM, Gabrielsson S, Gho YS, Gupta D, Harsha HC, Hendrix A, Hill AF, Inal JM, Jenster G, Krämer-Albers EM, Lim SK, Llorente A, Lötvall J, Marcilla A, Mincheva-Nilsson L, Nazarenko I, Nieuwland R, Nolte-'t Hoen EN, Pandey A, Patel T, Piper MG, Pluchino S, Prasad TS, Rajendran L, Raposo G, Record M, Reid GE, Sánchez-Madrid F, Schiffelers RM, Siljander P, Stensballe A, Stoorvogel W, Taylor D, Thery C, Valadi H, van Balkom BW, Vázquez J, Vidal M, Wauben MH, Yáñez-Mó M, Zoeller M, Mathivanan S