Dr Aled Clayton
Senior Lecturer, Institute of Cancer & Genetics
The group's aims are to better understand the complex roles of exosomes in cancer. Exosomes are nano-metre sized vesicles, produced in abundance by malignant cells. Their physiological functions remain incompletely understood.
Data from our group demonstrate exosomes as a mechanism for immune evasion, as cancer exosomes can negatively regulate T cell and NK cell functions. Cancer exosomes may also exert some influences within the microenvironment which also assist disease progression.
The molecular mechanisms underlying these effects are being examined, to aid in the design of future therapies targeted to attenuating these and other exosomal functions.
Recent key publications
- Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation. Plos Biol, Volume 10, 12 2012 p. e1001450
- Cancer exosomes express CD39 and CD73, which suppress T cells through adenosine production. J Immunol, Volume 187, 2 July 2011 pp.676-683
- Cancer exosomes trigger fibroblast to myofibroblast differentiation. Cancer Res, Volume 70, 23 December 2010 pp.9621-9630
- Proteomics analysis of bladder cancer exosomes. Mol Cell Proteomics, Volume 9, 6 June 2010 pp.1324-1338
- Exosomes in tumour immunity Current Oncology, Volume 16, 3 June 2009 pp.187-190
- Human tumor-derived exosomes down-modulate NKG2D expression. J Immunol, Volume 180, 11 June 2008 pp.7249-7258