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Medical Biochemistry

The Department of Medical Biochemistry undertakes a wide range of clinical, teaching and research activities in both laboratory and clinical aspects of biochemistry. We have close links with the Cardiff and Vale UHB Department of Medical Biochemistry and Immunology, where academic staff also provide clinical services. The interests of the department include laboratory and clinical aspects of the porphyrias, lysosomal storage diseases and other inherited metabolic disorders, endocrinology, toxicology, familial hypercholesterolaemia and other lipid disorders. We are affiliated to the Cardiovascular Biology & Metabolism group within IMEM.

Porphyrias

Dr Michael Badminton heads the Cardiff porphyria service which provides laboratory diagnostics and clinical advice. Cardiff is also a designated centre for the National Acute Porphyria Service and has an international reputation in the field. The unit undertakes both clinical and laboratory research in acute and cutaneous porphyrias and collaborates widely both locally, nationally and internationally.

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Inherited Metabolic Disease and Newborn Screening

Dr Duncan Cole heads the adult inherited metabolic disease service, which includes the All Wales Lysosomal Storage Disease service. Dr Cole also has responsibility for the special chemistry section of clinical laboratory, which provides a wide range of metabolic and specialist testing to hospitals across Wales and the rest of the UK. A variety of collaborative projects are ongoing, and the metabolic unit participates in a number of international disease registries.

Dr Stuart Moat is a Consultant Clinical Scientist and Honorary Lecturer in the School of Medicine. Dr Moat is also the Director of the Wales Newborn Screening laboratory which also provides a range of metabolic biochemistry investigations. He also has a long-standing research interest in B-vitamin metabolism and paediatric metabolic biochemistry. Recently, research in collaboration with Prof Ian Weeks in the Institute of Translation, Innovation, Methodology & Engagement has focussed on the development of novel assays for the screening of newborns for a range of inherited metabolic disorders.

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Lipids and Apheresis

Dr Ian McDowell and Dr Dev Datta provide a lipidology service within the department, which includes the lipid apheresis unit. They also lead the All Wales Familial Hypercholesterolaemia cascade screening service in conjunction with Medical Genetics, which includes clinical research studies. Dr McDowell also has an interest in homocysteine as a risk factor in cardiovascular disease.

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Endocrinology

Dr Carol Evans is a Consultant Clinical Scientist and heads the Endocrine section of the clinical laboratory. She has active collaborations with Dr Aled Rees and Prof Marian Ludgate within IMEM.

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Toxicology

Dr Alun Hutchings is a Consultant Clinical Scientist and heads the regional Toxicology laboratory. He has close links with the Department of Pharmacology, Therapeutics & Toxicology , and has numerous collaborative research projects ongoing within Cardiff University and with other UK institutions.

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Clinical Immunology

The three Clinical Immunologists in the clinical laboratory department, Dr Stephen Jolles, Dr Paul Williams and Dr Tariq El-Shanawany, are associated with the Cardiff Institute of Infection & Immunity .

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Undergraduate Teaching

Dr Duncan Cole leads the Department’s teaching which is delivered across all years of the undergraduate medical degree programme. He is also the lead for the Homeostasis panel (years 1 – 3) and a member of the final year examination executive. Dr Cole is actively engaged in the C21 curriculum project , and is the chair of the Clinical Biochemistry and Immunology learning outcomes group, and is a member of both the Phase 1 and Phase 2 working groups. All members of the academic and clinical department contribute to undergraduate and postgraduate training in clinical and laboratory medicine.